http://askdrvic.com; http://www.drvicmax.com Osteoarthritis is a natural and unfortunate consequence of aging joints. ... The interrelationship between SAMe and glutathione production. More studies are available online; search “glutathione and osteoarthritis” in PubMed. Traditional treatment involves use of non steroidal anti-inflammatory. It was observed that osteoarthritis patients were more susceptible to oxidative damage than controls. SAM-E converts to glutathione, the most important substance in the liver. ... In treating osteoarthritis, SAM-E protects both the synovial fluid. Ascorbic acid, catalase glutathione, glutathione peroxidase, glutathione -s-transferase, malondi aldehyde, osteoarthritis, superoxide dismutase. References for Osteoarthritis. Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. CATALASE AND GLUTATHIONE PEROXlDASE IN ERYTHROCYTES IN OSTEOARTHRITIS PATIENTS.